JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB₁ and peripheral CB₂ receptors (K_i = 9.0 and 2.94 nM, respectively).This cannabimimetic compound has frequently been found in herbal blends.  JWH 018  is distinguished by a terminal epoxide group on the alkyl chain. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.

XLR11 is a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB₂ receptor over the central CB₁ receptor. It also features an N-(5-fluoropentyl) chain, which increases binding to both CB receptors. FUB-144 is a derivative of XLR11 in which the 5-fluoropentyl side chain is replaced by a 4-fluorobenzyl group, a functional group also found in the indazole-based synthetic cannabinoids AB-FUBINACA and ADB-FUBINACA. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

JWH 201 is a synthetic cannabinoid (CB) with relatively poor affinities for both CB₁ (K_i = 1.1 μM) and CB₂ (K_i = 0.44 μM) receptors. It is a para-methoxy analog of the more potent cannabimimetic